Purkinje cells PCs are more resistant to ischemia than myocardial cells, and are suspected to participate in ventricular arrhythmias following myocardial infarction MI. Histological studies afford little evidence on the behavior and adaptation of PCs in the different stages of MI, especially in the chronic stage, and no quantitative data have been reported to date beyond subjective qualitative depictions. The present study uses a porcine model to present the first quantitative analysis of the distal cardiac conduction system and the first reported change in the spatial distribution of PCs in three representative stages of MI: an acute model both with and without reperfusion; a subacute model one week after reperfusion; and a chronic model one month after reperfusion.
The pathological hallmark of acute MI is coagulative necrosis of the myocardium.
Clinical significance of histological features of thrombi in patients with myocardial infarction. Mailling Address. All patients were monitored during hospitalization and thirty days after the event.
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